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matrigel with erastin  (MedChemExpress)


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    MedChemExpress matrigel with erastin
    <t>Erastin</t> treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Matrigel With Erastin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1068 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/matrigel+with+erastin/Erastin/pmc12964050-93-50-55
    Average 99 stars, based on 1068 article reviews
    matrigel with erastin - by Bioz Stars, 2026-09
    99/100 stars

    Images

    1) Product Images from "Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system"

    Article Title: Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system

    Journal: Materials Today Bio

    doi: 10.1016/j.mtbio.2026.102965

    Erastin treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Figure Legend Snippet: Erastin treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Techniques Used: Immunohistochemical staining, Staining, Colorimetric Assay, Fluorescence

    Related Articles

    In Vitro:

    Article Title: Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system
    Article Snippet: .. The culture medium was replenished every 48 h. The cryopreserved ovarian tissues were randomly divided into six groups for in vitro experiments: (1) Control group (Ctrl), freshly isolated ovaries encapsulated in Matrigel; (2) Cryopreservation group (Cryo), frozen-thawed ovaries encapsulated in Matrigel; (3) Erastin group (Ers), freshly isolated ovaries encapsulated in Matrigel with erastin (30 μM; MedChemExpress, USA) during the first 2 days of culture; (4) MSC group, frozen-thawed ovaries encapsulated in Matrigel and cocultured with UC-MSCs for 4 days; (5) Fer-1 group (Fer-1), frozen-thawed ovaries encapsulated in Matrigel with Fer-1 (50 μM; MedChemExpress, USA) during the first 2 days of culture; and (6) Erastin + MSC group (Ers + MSC), freshly isolated ovaries encapsulated in Matrigel, treated with erastin for the first 2 days and subsequently cocultured with UC-MSCs for the remaining 2 days. ..

    Control:

    Article Title: Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system
    Article Snippet: .. The culture medium was replenished every 48 h. The cryopreserved ovarian tissues were randomly divided into six groups for in vitro experiments: (1) Control group (Ctrl), freshly isolated ovaries encapsulated in Matrigel; (2) Cryopreservation group (Cryo), frozen-thawed ovaries encapsulated in Matrigel; (3) Erastin group (Ers), freshly isolated ovaries encapsulated in Matrigel with erastin (30 μM; MedChemExpress, USA) during the first 2 days of culture; (4) MSC group, frozen-thawed ovaries encapsulated in Matrigel and cocultured with UC-MSCs for 4 days; (5) Fer-1 group (Fer-1), frozen-thawed ovaries encapsulated in Matrigel with Fer-1 (50 μM; MedChemExpress, USA) during the first 2 days of culture; and (6) Erastin + MSC group (Ers + MSC), freshly isolated ovaries encapsulated in Matrigel, treated with erastin for the first 2 days and subsequently cocultured with UC-MSCs for the remaining 2 days. ..

    Isolation:

    Article Title: Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system
    Article Snippet: .. The culture medium was replenished every 48 h. The cryopreserved ovarian tissues were randomly divided into six groups for in vitro experiments: (1) Control group (Ctrl), freshly isolated ovaries encapsulated in Matrigel; (2) Cryopreservation group (Cryo), frozen-thawed ovaries encapsulated in Matrigel; (3) Erastin group (Ers), freshly isolated ovaries encapsulated in Matrigel with erastin (30 μM; MedChemExpress, USA) during the first 2 days of culture; (4) MSC group, frozen-thawed ovaries encapsulated in Matrigel and cocultured with UC-MSCs for 4 days; (5) Fer-1 group (Fer-1), frozen-thawed ovaries encapsulated in Matrigel with Fer-1 (50 μM; MedChemExpress, USA) during the first 2 days of culture; and (6) Erastin + MSC group (Ers + MSC), freshly isolated ovaries encapsulated in Matrigel, treated with erastin for the first 2 days and subsequently cocultured with UC-MSCs for the remaining 2 days. ..



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    matrigel with erastin  (MedChemExpress)
    99
    MedChemExpress matrigel with erastin
    <t>Erastin</t> treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Matrigel With Erastin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/matrigel+with+erastin/Erastin/pmc12964050-93-50-55
    Average 99 stars, based on 1 article reviews
    matrigel with erastin - by Bioz Stars, 2026-09
    99/100 stars
    		  Buy from Supplier

    Image Search Results


    Erastin treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Journal: Materials Today Bio

    Article Title: Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system

    doi: 10.1016/j.mtbio.2026.102965

    Figure Lengend Snippet: Erastin treatment mimicked the ferroptosis phenotypes observed in cryopreserved ovarian tissue. (A) Immunohistochemical staining of GPX4 and ACSL4 in fresh ovarian tissue (Ctrl), cryopreserved tissue (Cryo), and fresh tissue treated with the ferroptosis inducer erastin (Ers). Scale bar, 50 μm. (B) Quantification of the mean optical density for GPX4 and ACSL4 staining in each group ( n = 8). (C) Measurement of Fe 2+ concentrations by colorimetric assay in the Ctrl, Cryo, and Ers groups ( n = 6). (D) Quantification of GSH levels in ovarian tissues via a colorimetric assay ( n = 5). (E) Representative confocal images of oxidized (green) and reduced (red) C11-BODIPY staining in ovarian tissues. Scale bar, 50 μm. (F) Quantification of lipid peroxidation expressed as the oxidized/reduced C11-BODIPY fluorescence ratio ( n = 5). Data are presented as mean ± SD. One-way ANOVA followed by LSD post hoc test. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Article Snippet: The culture medium was replenished every 48 h. The cryopreserved ovarian tissues were randomly divided into six groups for in vitro experiments: (1) Control group (Ctrl), freshly isolated ovaries encapsulated in Matrigel; (2) Cryopreservation group (Cryo), frozen-thawed ovaries encapsulated in Matrigel; (3) Erastin group (Ers), freshly isolated ovaries encapsulated in Matrigel with erastin (30 μM; MedChemExpress, USA) during the first 2 days of culture; (4) MSC group, frozen-thawed ovaries encapsulated in Matrigel and cocultured with UC-MSCs for 4 days; (5) Fer-1 group (Fer-1), frozen-thawed ovaries encapsulated in Matrigel with Fer-1 (50 μM; MedChemExpress, USA) during the first 2 days of culture; and (6) Erastin + MSC group (Ers + MSC), freshly isolated ovaries encapsulated in Matrigel, treated with erastin for the first 2 days and subsequently cocultured with UC-MSCs for the remaining 2 days.

    Techniques: Immunohistochemical staining, Staining, Colorimetric Assay, Fluorescence